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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Ameliorative effect of omega-3-Fatty acid on Cypermethrin induced developmental neurotoxicity in chick embryo |
| Authors Name: | Rinku , Dr. Dhirender Kaushik , Dr. Shivkant Sharma |
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IJNRD_205560
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| Published Paper Id: | IJNRD2309365 |
| Published In: | Volume 8 Issue 9, September-2023 |
| DOI: | |
| Abstract: | Pyrethroids are a class of insecticides that are used for crop protection worldwide. Cypermethrin, a class II pyrethroid, is used to control insects in the household and agricultural fields. It crosses the blood-brain barrier and induces neurotoxicity and motor deficits. Cypermethrin prolongs the opening of sodium channel, thereby causing depolarisation leading to hyper-excitation of the central nervous system. It also modulates chloride, voltage-gated calcium and potassium channels, alters the activity of glutamate and acetylcholine receptors and adenosine tri-phosphatases and induces DNA damage and oxidative stress in the neuronal cells. The present study aimed to evaluate the Cypermethrin induced developmental neurotoxicity in chick embryo. We have also investigated the ameliorative effect of omega-3-Fatty acid on Cypermethrin induced toxicity. Sixty eggs (0 day) of species Gallus domesticus were used and divided into six groups -control, vehicle, CYP (50 ppm), CYP (100ppm), CYP (50ppm) + DHA (200µg/egg) and CYP (100ppm) + DHA (200µg/egg) were kept in an incubator at 38±0.5°C with a relative humidity of 60-70% and proper ventilation. Control group have untreated eggs. The vehicle group was supplied with distilled water while the eggs in remaining four groups were administered by air sac method. 16-day old embryos were recovered from all the groups for assessing morphometric, biochemical parameters and histopathology. Results showed that group treated with higher dose of cypermethrin (100ppm) showed a marked decrease in morphometric parameters. Administration of docosahexanoic acid (200µg) in combination with cypermethrin ameliorated the neurological changes produced by Cypermethrin alone in the chick embryo. |
| Keywords: | Cypermethrin (CYP), Omega-3-fatty acid, docosahexanoic acid (DHA), Gallus domesticus, morphometric parameters. |
| Cite Article: | "Ameliorative effect of omega-3-Fatty acid on Cypermethrin induced developmental neurotoxicity in chick embryo", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 9, page no.d512-d525, September-2023, Available :http://www.ijnrd.org/papers/IJNRD2309365.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2309365 Registration ID: 205560 Published In: Volume 8 Issue 9, September-2023 DOI (Digital Object Identifier): Page No: d512-d525 Country: Gurugram, Haryana, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2309365 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2309365 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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