INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
Background
Non-tuberculous mycobacteria (NTM) are a large family of acid-fast bacteria, widespread in the environment. In children, NTM cause lymphadenitis, skin and soft tissue infections, and occasionally lung disease and disseminated infections. These manifestations can be indistinguishable from tuberculosis (TB) on the basis of clinical and radiological findings and tuberculin skin testing. Treatment of NTM infections is different from the treatment of TB and depends on the strain and anatomical site of infection and often involves antibiotic combinations, surgery, or both.
Case characteristics
A 2-month-old infant girl had fever and progressive breathing difficulty at 1.5 months of age. She was formula-fed and had failure to thrive (birth weight 3kg, admission weight 3.3kg). X-rays revealed persistent bilateral consolidation. High resolution computed tomography (HRCT) of the chest revealed air space opacification in the right upper and left lower lobes. A bronchoscopy done revealed gastro-oesophageal reflux disease and BAL culture revealed multidrug resistant (MDR) Klebsiella pneumoniae which was treated with Inj. meropenem and Inj. cotrimoxazole as per sensitivity for 14 days. Though the child was weaned to oxygen support, she had re-appearance of fever and distress. TB culture (MGIT culture) revealed NTM; sensitive drugs rifampin, ethambutol and ofloxacin were given for 1 year, with close follow up and she is well on follow-up (current weight 8.3kg and length 71cm)
Message
The isolation of an NTM organism does not necessarily equate with active infection; clinical, radiologic, and microbiologic parameters are all needed to establish the diagnosis of infection. Eradication of disease with drug therapy requires prolonged combination therapy. Surgical resection is often indicated in localized disease, in the presence of drug resistant organisms, or in some cases, of failure of medical therapy.
"Persistent pneumonia in an infant with achalasia cardia due to non-tuberculous mycobacterium", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 9, page no.d736-d739, September-2023, Available :http://www.ijnrd.org/papers/IJNRD2309388.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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