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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Anti-cancer activity of 1,3,4-oxadiazole and its derivative |
| Authors Name: | KOUSIK MAPARU , RITAM MUKHERJEE , DHRITA CHATTERJEE |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_206247
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| Published Paper Id: | IJNRD2310013 |
| Published In: | Volume 8 Issue 10, October-2023 |
| DOI: | http://doi.one/10.1729/Journal.36368 |
| Abstract: | Nowadays cancer is a leading cause of death, the most common cancers worldwide are breast, colorectal, and lung cancer. Data from the International agency for Research on Cancer (IARC) says 19.3 million new cases of cancer and 10 million deaths. Oxidaizole derivatives are compounds having 5-membered rings containing one oxygen and two nitrogen atoms such as oxacillin, sulfamethoxazole, acivicin, and cycloserine have containing oxadiazole ring . 1,3,4 oxadiazole derivatives have the demand for researchers because of their various activities such as antibacterial, anti-tumor, antiviral, and antioxidant. Nowadays there are potent medicines in the market having anticancer activity, used worldwide. Some examples of anticancer agents available in the market are bleomycin and tiazofurin. There are some various mechanisms of action of 1,3,4 oxadiazole derivatives for anticancer activity, by acting on some enzymes likes thymidylate-syn-thase, HDAC(histone deacetylase ), topoisomerase II, telomerase, thymidine phosphorylase to stop proliferation and also acting some pathways likes inhibiting telomerase activity, focal adhesion kinase(FAK) inhibitors, targeting thymidylate synthase, an inhibitor of the B-cell lymphoma 2, inhibitor of NF-kB signaling pathway and targeting tubulin polymerization. So,1,3,4-oxadiazole used as a promising anticancer drug in future. |
| Keywords: | Oxadiazole ring , anticancer activity , HDAC , Proliferation , anti-tumor |
| Cite Article: | "Anti-cancer activity of 1,3,4-oxadiazole and its derivative", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 10, page no.a84-a95, October-2023, Available :http://www.ijnrd.org/papers/IJNRD2310013.pdf |
| Downloads: | 000118781 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2310013 Registration ID: 206247 Published In: Volume 8 Issue 10, October-2023 DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.36368 Page No: a84-a95 Country: East Medinipur , West Bengal , India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2310013 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2310013 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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