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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | FORMULATION AND EVALUATION OF BILAYER ANTI DIABETIC TABLETS |
| Authors Name: | Sandesh Kumar , Yograj Mahajan , Vishal Gupta , Harish kumar Singh , Kumar Abhishek |
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| Author Reg. ID: |
IJNRD_207785
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| Published Paper Id: | IJNRD2310371 |
| Published In: | Volume 8 Issue 10, October-2023 |
| DOI: | |
| Abstract: | Bilayer tablets of an Glimepiride hydrochloride is to formulate, and evaluate for oral sustained drug release, in pharmaceutical system to enhance its oral bioavailability, Reduction in drug toxicity, Reduction in dosing frequency of drug. Biphasic release is characterized by rapid initial release of the drug, followed by sustained rate of release. The drug released by the initial pulse, quickly attains the therapeutic plasma drug levels and ameliorates the slow onset of action of sustained release layer. This increases patient compliance as the patient is quickly relief. Such type of drug delivery systems is designed to deliver the drug in such a way that the drug level is maintained within the therapeutic window for a period as long as the system continues to deliver the drug and to avoid fluctuations in plasma drug level. The purpose of the research work was formulation development and evaluation bi-layer floating tablets of glimepiride to improve the oral therapeutic efficacy of these drugs exhibit pH dependent solubility and show good permeability from stomach and upper part of the small intestine into systemic circulation. Direct compression method form glimepiride was used to formulate bi-layer floating tablets. |
| Keywords: | Glimeperide, Bilayer tablet, Xanthan gum, Magnesium Stearate Crospovidone, crosscarmellose sodium, microcrystalline cellulose |
| Cite Article: | "FORMULATION AND EVALUATION OF BILAYER ANTI DIABETIC TABLETS", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 10, page no.d522-d538, October-2023, Available :http://www.ijnrd.org/papers/IJNRD2310371.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2310371 Registration ID: 207785 Published In: Volume 8 Issue 10, October-2023 DOI (Digital Object Identifier): Page No: d522-d538 Country: -, -, India Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2310371 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2310371 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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