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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | COMPARATIVE STUDY ON EFFICACY AND SAFETY OF VILDAGLIPTIN-METFORMIN VS GLIMEPIRIDE-METFORMIN IN PATIENTS WITH TYPE 2 DIABETES MELLITUS |
| Authors Name: | Bismi B , Jyothy A , Krishna M S , Sabna Sobhanan |
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IJNRD_206919
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| Published Paper Id: | IJNRD2311002 |
| Published In: | Volume 8 Issue 11, November-2023 |
| DOI: | |
| Abstract: | The aim of the study was to compare the efficacy and safety of vildagliptin-metformin Vs glimepiride metformin in patients with type 2 DM. A comparative study was conducted over a period of three months in a tertiary care hospital. In this study the primary goal was a reduction in HbA1c from baseline and secondary goal included fasting plasma glucose (FPG) or postprandial glucose (PPG) reduction from baseline, as well as HbA1c responder rate and HbA1c reduction according to baseline HbA1c category. Among the study population N=102, comparable HbA1c reduction was observed with a mean±standard deviation change from baseline in the vildagliptin group and -1.00±1.32% in the glimepiride group. A similar reduction in PPG (vildagliptin group 3.53±4.11 mmol/L vs. the glimepiride group 3.72±4.17 mmol/L) was demonstrated, and the decrements in FPG (vildagliptin group 1.54±2.41 mmol/L vs. glimepiride group 2.16±2.51 mmol/L) were not different between groups. The proportion of patients who achieved an HbA1c less than 7% in the vildagliptin group and 56.0% in the glimepiride group. An average body weight gain in the glimepiride group was observed in contrast with the weight gain noted in the vildagliptin group. A 10-fold lower incidence of hypoglycemia was demonstrated in the vildagliptin group, in addition to an absence of severe hypoglycemia. The study concluded that vildagliptin-metformin treatment provided blood glucose control efficacy comparable to that of glimepiride-metformin treatment and resulted in better adverse event profiles with lower risks of hypoglycemia and weight gain. |
| Keywords: | DM-Diabetes Mellitus, PPG-Post prandial glucose, FPG-Fasting blood plasma glucose, HbA1c-Hemoglobin A1C |
| Cite Article: | "COMPARATIVE STUDY ON EFFICACY AND SAFETY OF VILDAGLIPTIN-METFORMIN VS GLIMEPIRIDE-METFORMIN IN PATIENTS WITH TYPE 2 DIABETES MELLITUS", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 11, page no.a26-a33, November-2023, Available :http://www.ijnrd.org/papers/IJNRD2311002.pdf |
| Downloads: | 000118756 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2311002 Registration ID: 206919 Published In: Volume 8 Issue 11, November-2023 DOI (Digital Object Identifier): Page No: a26-a33 Country: Alappuzha , Kerala, India Research Area: Science Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2311002 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2311002 |
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ISSN: 2456-4184
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