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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | EVALUATION OF THE BINDING AND DISINTEGRANT ACTIVITIES OF STARCHES FROM UNRIPE BANANA FRUITS AND TUBERS OF IRISH POTATO ON DICLOFENAC SODIUM TABLET. |
| Authors Name: | Ordu, John I , Eliozu Williams C |
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IJNRD_197232
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| Published Paper Id: | IJNRD2311028 |
| Published In: | Volume 8 Issue 11, November-2023 |
| DOI: | |
| Abstract: | ABSTRACT This study aims to assess the binding and disintegrant properties of starch(es) obtained from the fruits of unripe banana (Musa acuminata) and that obtained from the tuber of Irish potato (Solanum tuberosum) on diclofenac sodium tablets formulation. The banana fruits and irish potato tubers were processed and treated to prevent oxidation, filtered, dried, pulverised and packaged for analysis while granules for tablet formulation was obtained by wet granulation technique. In the process, four batches including, W1 (banana and Irish potato starch, ratio: 2:1), W2 (banana and Irish potato starch ratio:1:2), W3 (banana starch only) and W4 (Irish potato starch only) were prepared. Physico-technical properties of the granules were assessed then granules, compressed into tablets using single punch tableting machine and the resulting tablets, evaluated adopting various characterization techniques. The results obtained depicts the banana and Irish potato starches as having a pH of 7.8 and 8.0 respectively. Further comparative studies showed that irish potato and banana starch(es), had swelling capacity of 51.9 and 12.65 respectively, but both had hydration /water absorption capacity of 2.145. There was significant difference (p<0.05) in the proximate analysis results of the starches. Physico technical analysis of the formed granules showed the flow rate of 10.03, 10.45g/s, Hausner’s ratio 1.10, 1.17 and Carr’s index 8.70,14.60 respectively for the irish potato and banana starch(es). Tablets compressed from some batches did not meet the hardness specifications as they fell below 4kgF especially, W2=3.9 and W4 = 3.5 kgF), The percentage losses after the friability test for all the formed batches, were less than 1.0. The tablets determined for the active drug content gave values within the range of 95-101% while the profile for percentage of drug release showed that batch W4 (81.64%) had the highest release rate followed by W3(43.55%), W1(41.30) and lastly W2(24.91%) within 60 minutes. |
| Keywords: | Key words: Starch, Musa acuminata , Solanum tuberosum, disintegrant, binder, diclofenac sodium tablets |
| Cite Article: | "EVALUATION OF THE BINDING AND DISINTEGRANT ACTIVITIES OF STARCHES FROM UNRIPE BANANA FRUITS AND TUBERS OF IRISH POTATO ON DICLOFENAC SODIUM TABLET.", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 11, page no.a241-a260, November-2023, Available :http://www.ijnrd.org/papers/IJNRD2311028.pdf |
| Downloads: | 000118753 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2311028 Registration ID: 197232 Published In: Volume 8 Issue 11, November-2023 DOI (Digital Object Identifier): Page No: a241-a260 Country: Port Harcourt, Rivers state, Nigeria Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2311028 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2311028 |
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