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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | EFFECTS OF ETHANOL LEAF EXTRACT OF VERNONIA AMYGDALINA D (BITTER LEAF) ON HAEMATOLOGY AND LIPID PROFILE OF APPARENTLY HEALTHY ALBINO RATS |
| Authors Name: | Enemali, Michael Okey , Ibrahim, Zakariyau , Ogana, Joy , Nwefia, Wilson Ifeanacho , Abdullahi Halimatu Sadiya |
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IJNRD_208934
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| Published Paper Id: | IJNRD2311158 |
| Published In: | Volume 8 Issue 11, November-2023 |
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| Abstract: | Abstract Bitter leaf (Vernonia amygdalina Delile), family Asteraceae or Compositae is a perennial shrub that is widely used locally in Nigeria for both therapeutic and nutritional purposes. This study was conducted to evaluate the phytochemical composition and the effect of ethanol leaf extract of the plant on haematological parameter and lipid profile of rat. Sixteen (16) albino wistar rats were randomly divided into four groups of 4 rats each. All groups were fed with growers mash. Groups 2, 3 and 4 further received daily oral doses of 200 mg, 300 mg and 400 mg per kg body weight of the extract, respectively. After 14 days of administration, the animals were sacrificed and blood was collected through orbital-plexus. The presence of alkaloids, tannins, phenolics, saponins, flavonoids, terpenoids, glycosides, carbohydrate and resins were detected with saponins as the most abundant while steroids was found to be absent. Results equally showed a non-significant (p>0.05) decrease at the highest concentration (400 mg/kg body weight) in PCV (27.2± 1.7), Hb (75.30 ± 1.10), RBC (0.52± 0.01) and PLT (142.50 ±1.30). However, WBC (8.58± 0.50), MCH (153.69±2.80), MCV (0.41±0.0) and MCHC (332.0±2.90) increase significantly (p<0.05) at 400mg/kg when compare to control (41.0±1.8), (135.80±2.50), (1.31±0.03), (303.80±5.10), (1.47±0.40), (102.99±1.40), (0.33± 0.30) and (315.80±1.70) respectively. Result also indicated a non-significant (p>0.05) decrease in the lipid profile of the test rats relative to control. It was therefore concluded that the bitter leaf extract is rich in bioactive compounds but negatively affect the haematological parameters at 400mg/kg body weight with no remarkable effect on the lipid profile at the administered doses within the period of the research. |
| Keywords: | Bioactive compounds, Bitter leaf, Haematological parameters, Lipid profile, Vernonia amygdalina Delile. |
| Cite Article: | "EFFECTS OF ETHANOL LEAF EXTRACT OF VERNONIA AMYGDALINA D (BITTER LEAF) ON HAEMATOLOGY AND LIPID PROFILE OF APPARENTLY HEALTHY ALBINO RATS", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 11, page no.b453-b464, November-2023, Available :http://www.ijnrd.org/papers/IJNRD2311158.pdf |
| Downloads: | 000118757 |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2311158 Registration ID: 208934 Published In: Volume 8 Issue 11, November-2023 DOI (Digital Object Identifier): Page No: b453-b464 Country: Nnamdi Azikiwe University, Awka, Anambra, Nigeria Research Area: Life Sciences Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2311158 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2311158 |
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