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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | A STUDY ON EFFICACY OF PRE-MEDICATIONS IN THE MANAGEMENT OF HYPERSENSITIVITY REACTIONS ASSOCIATED WITH CHEMOTHERAPY AMONG BREAST CANCER PATIENTS |
| Authors Name: | Dr. MUCHUKOTA SUSHMA , PRIYANKA C , SWATHI , ALKAYUM AHMAD , IFTHIKAR, Dr. C D SARASWATHI, SABITHA SUJEETH |
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IJNRD_210856
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| Published Paper Id: | IJNRD2312199 |
| Published In: | Volume 8 Issue 12, December-2023 |
| DOI: | |
| Abstract: | ABSTRACT: - Background: The estimation of 2.3 million (11.7% of all cancer cases) new cases of breast cancer diagnosed every year globally, the death rate increased over the last 3 decades, it is the 5th leading cause of mortality worldwide with 685000 deaths. Chemotherapy is a crucial component of breast cancer treatment, yet it is often accompanied by the risk of hypersensitivity reactions (HSRs). Objective: Evaluating hypersensitivity reactions in breast cancer patients involves assessing the effectiveness of premedication, treatment methods, and standardized desensitization protocols to manage reactions and implementing risk management measures. Methodology: This is Hospital based prospective observational study was conducted in ESI hospital Indira nagar Bangalore, the present study was conducted among 85 patients for a period of six months from April 2023 – September 2023, involves breast cancer patients receiving chemotherapy. Results: Among the 85 breast cancer patients in our study, 40% were in stage 2 were classified as having a major disease severity, while only 5.88% of those in stage 4 had the lowest severity. Hypersensitivity reactions were prevalent, with 64.7% experiencing grade Ⅰ and Ⅱ reactions, and 35.29% having grade Ⅲ and Ⅳ reactions. Notably, platinum agents, specifically carboplatin and oxaliplatin, were responsible for hypersensitivity reactions in 54.11% of cases, while taxanes (paclitaxel and docetaxel) were associated with reactions in 32.9% of cases. Additionally, 38% of the participants received monoclonal antibodies as part of their treatment. Conclusion: Breast cancer patients receiving chemotherapy, the present study found significant presence of hypersensitivity reactions, with the majority falling into grade Ⅰ and Ⅱ categories. These reactions were most commonly associated with platinum agents and taxanes. A substantial portion of patients received monoclonal antibodies as part of their treatment. These findings underscore the need for tailored premedication protocols and risk management measures to improve the safety and efficacy of breast cancer therapy, particularly for those at risk of hypersensitivity reactions. |
| Keywords: | Breast cancer, Hypersensitivity reactions, Premedication, Desensitization |
| Cite Article: | "A STUDY ON EFFICACY OF PRE-MEDICATIONS IN THE MANAGEMENT OF HYPERSENSITIVITY REACTIONS ASSOCIATED WITH CHEMOTHERAPY AMONG BREAST CANCER PATIENTS", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 12, page no.b792-b800, December-2023, Available :http://www.ijnrd.org/papers/IJNRD2312199.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2312199 Registration ID: 210856 Published In: Volume 8 Issue 12, December-2023 DOI (Digital Object Identifier): Page No: b792-b800 Country: -, -, India Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2312199 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2312199 |
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ISSN: 2456-4184
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