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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | To evaluate Angiogenic potential of different medicinal herbs from CAM Assay |
| Authors Name: | Rafat Abdul Rauf Moosa , Bhumika Ajay Mishra , Dr. Aparna Deshmukh |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_209852
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| Published Paper Id: | IJNRD2312218 |
| Published In: | Volume 8 Issue 12, December-2023 |
| DOI: | http://doi.one/10.1729/Journal.37161 |
| Abstract: | Angiogenesis is a complex process that involves the growth of new blood vessels from existing ones, and defects in the control of angiogenesis have been implicated in several pathological processes, including diabetic and retinopathy.[1] To investigate the potential vasculogenic activity of plants, this study evaluated the angiogenic potential of three herbaceous plants, namely: Centella asiatica, Cissus quadrangularis, and Madhuka longifolia by chick chorioallantoic membrane (CAM) assay, a high-density microvasculature extra-embryonic membrane that supports embryonic development in avian species.[2] CAM assay is a well-established tool for investigating in vivo mechanisms of angiogenesis regulation.[3] These plants have been used in various traditional medicinal practices, but their therapeutic efficacy is not fully understood. The CAM from chicken embryos was treated with various concentrations of these three herbs/plants extracted to examine their angiogenic activity.[5] The results showed that all the plant extracts have the potential to induce angiogenesis in the CAM assay. The observed angiogenic activity was measured using various parameters, including increased vascularization, higher branching complexity, and increased capillary density. The induced angiogenic activity by the plant extracts was found to be concentration-dependent and showed a dose-response relationship. The angiogenic activity of the plant extracts has significant potential for therapeutic use in promoting tissue growth and repair, as well as in the treatment of various vascular disorders.[7] A detailed understanding of the mechanism of action, optimization of dosage and suitable formulation of these herbal extracts would enable us to consider a practical option and alternative therapies in the treatment of vascular disorders. |
| Keywords: | angiogenesis, CAM Assay, blood vessels, dosage, Centella asiatica, Cissus quadrangularis, Madhuca longifolia, vasculature, optimization, angiogenic activity. |
| Cite Article: | "To evaluate Angiogenic potential of different medicinal herbs from CAM Assay", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 12, page no.c166-c172, December-2023, Available :http://www.ijnrd.org/papers/IJNRD2312218.pdf |
| Downloads: | 000118757 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2312218 Registration ID: 209852 Published In: Volume 8 Issue 12, December-2023 DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.37161 Page No: c166-c172 Country: mumbai , Maharashtra, India Research Area: Biological Science Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2312218 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2312218 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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