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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | FORMULATE AND EVALUATE THE TRAMADOL HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLETS USING NATURAL POLYMER (TAMARINDUS INDICA LINN. SEEDS) |
| Authors Name: | Dr MEKALA SUNIL , CHILAKA SURESH , CHIRATHNAGANDLA HEMALATHA , SIDDA AKASH , THOKALA ADITHYA, YANAMADALA SAIPAVANI |
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IJNRD_211865
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| Published Paper Id: | IJNRD2401054 |
| Published In: | Volume 9 Issue 1, January-2024 |
| DOI: | |
| Abstract: | The aim of this project was to develop once daily controlled release matrix tablets of Tramadol HCl. Controlled release matrix tablets of Tramadol HCl using different polymers viz. Eudragit RS-100, Ethylcellulose, Carbopol 934Pand Polyvinyl Pyrolidone K-90 were formulated and evaluated. The tablets were prepared by wet granulation method. The tablets were evaluated for thickness, weight variation, hardness, friability, drug content and in-vitro dissolution studies. Different release models like zero order, first order, Higuchi etc were applied to in-vitro drug release data in order to evaluate the drug release mechanisms and kinetics. Three batches of matrix tablets were developed. Among these formulations, F5 formulation showed satisfactory physicochemical properties and drug content uniformity and controlled release of drug for 24 hours with maximum release of 95.73%. Matrix tablets with optimum concentration of ethyl cellulose, PVP K-90 were successfully developed and evaluated. |
| Keywords: | Matrix tablets, Eudragit RS-100, Ethylcellulose, Carbopol 934P, PVPK-90, Tramadol HCl. |
| Cite Article: | "FORMULATE AND EVALUATE THE TRAMADOL HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLETS USING NATURAL POLYMER (TAMARINDUS INDICA LINN. SEEDS)", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 1, page no.a468-a485, January-2024, Available :http://www.ijnrd.org/papers/IJNRD2401054.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2401054 Registration ID: 211865 Published In: Volume 9 Issue 1, January-2024 DOI (Digital Object Identifier): Page No: a468-a485 Country: -, -, India Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2401054 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2401054 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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