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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | HMGB1: Exploring scaffolding factors that shape chromosomal organization |
| Authors Name: | Bhumika Sureka , Arianna Broad |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_213063
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| Published Paper Id: | IJNRD2401272 |
| Published In: | Volume 9 Issue 1, January-2024 |
| DOI: | |
| Abstract: | HMGB1 (High mobility group box 1) is a non-histone nuclear protein that is either passively released following cell damage or actively secreted in response to inflammatory stimuli. It is a non-histone chromatin-associated protein that is generally found inside cells; however, it can be secreted into the extracellular environment by passive or active release. Extracellular HMGB1 interacts with a variety of receptors and interactors to regulate hematopoietic stem cell (HSC) proliferation, differentiation, mobilization, and senescence. In this review, we comprehensively evaluate HMGB1's emerging roles and how it influences chromosomal arrangement, starting with its biological structure, which is an evolutionarily conserved multifunctional protein by nature. A quick glance at the timelines of findings linked with HMGB1 reveals that the assembly of histones with DNA to create nucleosomes is well recognized, but the nature of non-histone participation is less clear. Throughout this paper, we aim to systematically review the various hypotheses regarding the role and importance of HMGB1 in chromatin-related processes. |
| Keywords: | Key Words: Non-histone proteins, adaptive immunity, damage associate molecular pattern (DAMP), immunogenic cell death (ICD), inflammation, innate immunity, tissue repair |
| Cite Article: | "HMGB1: Exploring scaffolding factors that shape chromosomal organization", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 1, page no.c563-c569, January-2024, Available :http://www.ijnrd.org/papers/IJNRD2401272.pdf |
| Downloads: | 000118759 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2401272 Registration ID: 213063 Published In: Volume 9 Issue 1, January-2024 DOI (Digital Object Identifier): Page No: c563-c569 Country: Bangalore, Karnataka, India Research Area: Biological Science Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2401272 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2401272 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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