INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
Fast dissolving tablet format designed to allow administration of an oral dose form in the absence of water or fluid intake. The tablets rapidly dissolve or disintegrate in the saliva. Formulation research is oriented towards increasing the efficacy of existing drug molecule thought novel concepts of drug delivery. Losartan potassium and Nifedipine widely used as an antihypertensive drug. The aim of this study was to improve the solubility of Losartan potassium and nifedipine and increasing its disintegration time by formulation of fast dissolving tablets by direct compression method and various ratios of cross povidone (CP) cross carmellose sodium (CCS) sodium starch glycolate (SSG) as Superdisintegrants. The tablet pre compression parameter e.g. angle of repose, bulk density, tapped density, carr’s compressibility index and hausner’s ratio and post compression parameter like drug content uniformity, hardness, wetting time, friability, thickness, disintegration time, were evaluated for each formulation and found satisfactory.
Keywords:
Losartan potassium, nifedipine, super disintegrants, fast dissolving tablets (FDTS).
Cite Article:
"FORMULATION, DEVELOPMENT AND EVALUATION OF FAST DESSOLVING TABLET OF LOSARTAN POTASSIUM AND NIFEDIPINE", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 1, page no.d157-d166, January-2024, Available :http://www.ijnrd.org/papers/IJNRD2401322.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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