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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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Volume 9 | Issue 5
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| Paper Title: | Development and Evaluation of Fast Dissolving Tablets of Diltiazem Hydrochloride |
| Authors Name: | Pramod Kharel , Sujan Neupane , Jaya Bahadur Ghale |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_215185
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| Published Paper Id: | IJNRD2403174 |
| Published In: | Volume 9 Issue 3, March-2024 |
| DOI: | |
| Abstract: | This study has been carried out with a concept of formulating the fast dissolving tablets of Diltiazem Hydrochloride using various superdisintegrants. To create the dosage form, direct compression technique was used. A total for nine formulations were developed. The combination of synthetic (2-6%) and natural superdisintegrant (2-8%) was incorporated in all the formulations. All the formulations were evaluated for precompression and post compression evaluation parameters. From the observation, it was found that all the formulations were disintegrated within the time range of 27 - 64 seconds. All the prepared formulations complied with the Pharmacopoeial standard requirements of the drug contents. The optimized formulation F6 gave the best results in disintegration time and dissolution studies as compared to other created formulations. The research concluded that the nature of the superdisintegrants influenced the rate of disintegration and drug release rate. From the study, it was assumed that combination of superdisintegrants in certain amount or ratio can enhance the disintegration time for increasing patient compliance. |
| Keywords: | Diltiazem Hydrochloride, Fast Dissolving Tablets, Superdisintegrants, Direct Compression Technique, Combination |
| Cite Article: | "Development and Evaluation of Fast Dissolving Tablets of Diltiazem Hydrochloride", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 3, page no.b661-b666, March-2024, Available :http://www.ijnrd.org/papers/IJNRD2403174.pdf |
| Downloads: | 00039 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2403174 Registration ID: 215185 Published In: Volume 9 Issue 3, March-2024 DOI (Digital Object Identifier): Page No: b661-b666 Country: Kathmandu, Bagmati, Nepal Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2403174 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2403174 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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