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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Navigating Warfarin's Pharmacological Maze: A Review Of Drug-Drug Interactions |
| Authors Name: | Vishal K R , Syed Muhammad |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_216355
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| Published Paper Id: | IJNRD2403478 |
| Published In: | Volume 9 Issue 3, March-2024 |
| DOI: | |
| Abstract: | Warfarin, a commonly prescribed anticoagulant, has over 250 known drug interactions that can significantly impact its therapeutic efficacy and safety. These interactions can occur with various medications, dietary supplements, and food items, with approximately 120 drugs or foods interacting with warfarin. The concurrent use of potentially interacting drugs during warfarin therapy is a common practice, with about half of patients receiving warfarin being prescribed concomitant drugs with high potential for interactions. These interactions can interfere with the maintenance of the International Normalized Ratio (INR) within the therapeutic range, leading to an increased risk of bleeding events. Studies have shown that the risk of serious bleeding in patients treated with warfarin is significantly higher when they are using potentially interacting drugs, compared to those on warfarin alone. The influence of drug-drug interactions on the risk of cerebral hemorrhage induced by warfarin has also been investigated. In conclusion, warfarin drug interactions are of great clinical importance, as a large number of patients who take concomitant medications that can increase the INR or the risk of bleeding are at risk. |
| Keywords: | Warfarin, Anticoagulation therapy, Drug interactions, Pharmacokinetics, Pharmacodynamics, Cytochrome P450 enzymes, Vitamin K antagonists, INR (International Normalized Ratio), Clinical implications, Adverse effects. |
| Cite Article: | "Navigating Warfarin's Pharmacological Maze: A Review Of Drug-Drug Interactions ", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 3, page no.e633-e639, March-2024, Available :http://www.ijnrd.org/papers/IJNRD2403478.pdf |
| Downloads: | 00048 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2403478 Registration ID: 216355 Published In: Volume 9 Issue 3, March-2024 DOI (Digital Object Identifier): Page No: e633-e639 Country: Bengaluru, Karnataka, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2403478 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2403478 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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