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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | FORMULATION, DEVELOPMENT AND EVALUATION OF in-situ FLOATING GEL OF PREGABALIN |
| Authors Name: | DR.B.V RAMANA , P.CHAITANYA , B.BALA KRISHNA , N.DINESH , B.MD. THOWSIF |
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IJNRD_219558
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| Published Paper Id: | IJNRDTH00135 |
| Published In: | Volume 9 Issue 4, April-2024 |
| DOI: | |
| Abstract: | Pregabalin (PRG), an analogue of gamma-aminobutyric acid, reduces the release of many neurotransmitters, including glutamate, and noradrenaline. It is used for the treatment of epilepsy; simple and complex partial convulsion. The present research work aims to ensure a high drug absorption by retarding the advancement of PRG formulation through the gastrointestinal tract. The work aims to design a controlled release PRG formulation which is administered as liquid and further gels in the stomach and floats in gastric juice. Materials and Methods: In situ gelling formulations were prepared using sodium alginate, calcium carbonate, sodium Bicarbonate, hydroxypropyl methylcellulose (HPMC) E-50M, and sodium bicarbonate. The prepared formulations were evaluated for solution viscosity, drug content, in vitro gelling studies, gel strength, and in vitro drug release. Results: The formulation containing 3% w/v sodium alginate and 0.6% w/v HPMC E-50 were considered optimum since it showed minimum floating lag time (18 s), optimum viscosity (287.3 cps). The optimized formulation follows first ordering Higuchi kinetic model with regression value 0.4767 representing diffusion mechanism of drug release. Conclusion: Floating in situ gelling system of PRG can be formulated using sodium alginate as a gelling polymer and calcium carbonate as a complexing agent to control the drug release for about 8 h for the treatment of epilepsy. |
| Keywords: | FORMULATION, DEVELOPMENT AND EVALUATION OF in-situ FLOATING GEL OF PREGABALIN |
| Cite Article: | "FORMULATION, DEVELOPMENT AND EVALUATION OF in-situ FLOATING GEL OF PREGABALIN", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 4, page no.865-914, April-2024, Available :http://www.ijnrd.org/papers/IJNRDTH00135.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRDTH00135 Registration ID: 219558 Published In: Volume 9 Issue 4, April-2024 DOI (Digital Object Identifier): Page No: 865-914 Country: -, -, India Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRDTH00135 Published Paper PDF: https://www.ijnrd.org/papers/IJNRDTH00135 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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