INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
The effectiveness of transdermal drug delivery has been limited due to the inability of most drugs to penetrate the skin at therapeutic rates. However, the use of micron-scale needles has been proposed as a solution to increase skin permeability and improve transdermal delivery, particularly for macromolecules. Microneedles have been fabricated with various sizes, shapes, and materials using microelectronics industry tools. Solid microneedles have been the focus of most drug delivery studies, as they have been shown to enhance skin permeability to a wide range of molecules and nanoparticles in vitro. In vivo studies have demonstrated successful delivery of oligonucleotides, insulin-induced reduction of blood glucose levels, and immune response induction from protein and DNA vaccines. Proteins and peptides have become a significant therapeutic modality for various diseases due to their high potency and specificity. However, their large molecular weight, poor stability, and conformational flexibility make them challenging to formulate and deliver. Injection is the primary route for clinical administration of protein and peptide drugs, but it often results in poor patient compliance. Microneedles offer a portable, minimally invasive solution that can overcome the skin barrier and create reversible microchannels for effective macromolecule permeation. This review highlights recent advances in microneedle-mediated transdermal delivery of protein and peptide drugs, with a focus on representative microneedle design and fabrication. The current application status of microneedle-mediated transdermal protein and peptide delivery, particularly in the fields of infectious disease, diabetes, cancer, and other disease therapies, is also summarized. Finally, the current status of clinical translation and future development perspectives are provided.
Keywords:
Transdermal, Microneedle, Protein, Peptide, nanoparticle, Hydrogel, cancer
Cite Article:
"Emerging developments in transdermal delivery via microneedles", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 11, page no.c237-c255, November-2023, Available :http://www.ijnrd.org/papers/IJNRD2311231.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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